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J.3rdet al (2016)

The main difference from adults is the reduction of the ATRA dose to 25 mg/m2 following the same scheme adopted by the APL0406 study of adults

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doi: 10.1016/j.molcel.2018.11.018 69 JinXChenDZhengR-HZhangHChenY-PXiangZ

The authors wish to thank Aakash Anandjiwala, Justin Geraghty, and Alexis Jennings-Coulibaly for their help in subject recruitment and data collection

DNA methylation is facilitated by SAMe which, again, requires methionine to be available in adequate amounts