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Description
The NADP-GDH activity of Gdh1 and Gdh3 isoforms is unidirectional and specific for glutamate synthesis, while glutamate catabolism is performed via the action of the oxidizing form of GDH (NAD-GDH) that is also present in the GDH pathway

, Banach, M

To assess levels of global DNA methylation, both fusion proteins are constructed using the DNA-binding domain of a methyl-CpG-binding domain protein such as MBD2, which has a 100-fold preference for methylated CpG sites over unmethylated CpG sites
doi:10.2353/ajpath.2006.050683 Murphy ME, Kehrer JP (1986) Activities of antioxidant enzymes in muscle, liver and lung of chickens with inherited muscular dystrophy

In GBM, CA9 (carbonic anhydrase 9), a downstream target gene of hypoxia-inducible factor HIF-1, has been shown to increase radiation-induced ferroptosis when it is knocked down, leading to a significant increase in intracellular ROS levels and increasing tumor cell sensitivity to radiation-induced oxidative stress (153)

J Ovarian Res 18 , 265 (2025)
