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10.4049/jimmunol.180.8.5653 9 AlvarezR.StorkC

Chronic Stress, Poor Sleep, Exposure to Environmental Toxins

[DOI] [PMC free article] [PubMed] [Google Scholar] 73.Kellett GL, Brot-Laroche E, Mace OJ, Leturque A

FIGURE 1 2.1 The inhibition of the system Xc -glutathione (GSH)glutathione peroxidase 4 (GPX4) axis The system Xc is a heterodimeric antiporter on the plasma membrane, which is composed of solute carrier family seven-member 11 (SLC7A11/xCT) and solute carrier family three member 2 (SLC3A2) with a disulfide bond ( functions to exchange extracellular cystine and intracellular glutamate at a ratio of 1:1 ( 2 O 2 to water ( GSH-GPX4 axis leads to the accumulation of lethal lipid peroxides and the occurrence of ferroptosis

Additionally, the testes naturally have low oxygen levels, which may contribute to germ cells using diverse metabolic pathways for energy at different developmental stages