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Like all retinoids, Retinol works best with nightly use, a good moisturizer, and daytime sunscreen

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Finally, no single biomarker was prespecified as a primary outcome, since our intention was to interrogate coordinated changes across mechanistic axes rather than to test a clinical endpoint

Lifetime TIRF microscopy To determine the effect of mutating the CHC-NTD Clathrin, Arrestin and W-boxes in how endocytosis progresses, cells tagged with Ent1/2p-mNeonGreen, Chc-mScarlet and Abp1-mTurquoise2 were used