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While the preclinical evidence is extensive, spanning hundreds of published studies across multiple tissue types and injury models, human data remain limited

Histology shows increased infiltration of CD45+, CD68+, and CD163+ immune cells, with a predominance of M2 macrophages, indicating chronic low-grade inflammation and tissue remodeling

400 mg per capsule (capsule weight: 500 mg)

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(melatonin) can repress aerobic glycolysis and increase mitochondrial oxidative phosphorylation, reversing the Warburg effect produced in cancer cells, an action that reduces proliferation and increases cell apoptosis [48]

Tetrahedron 50 , 1349313500 (1990)