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Liu X, Yi M, Jin R, Feng X, Ma L, Wang Y, et al

After implantation, IGF-I is produced in the human embryo (37), but until then the source of IGF-I is thought to be the female reproductive tract, and it is known that the availability of the IGF-I ligand is important for blastocyst growth in human in vitro fertilization - IVF (38)

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Most patients describe the sensation as a brief pinch followed by mild pressure