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To overcome this challenge, spatial transcriptomic methods present a powerful tool for the native detection of transcripts in situ within tissues, which simultaneously facilitates the validation of newly identified marker genes and the elucidation of spatially regulated expression 21,22,23,24,25

doi: 10.1016/S0022-2275(20)32522-0

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This suggests that, in the absence of SER-1, LSD may either exert a deleterious effect or counteract the lifespan increase typically observed in ser-1 mutants, as the average lifespan in this group approximated that of wild-type controls