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A chemical probe to directly modulate the incorporation of TRF1 into shelterin would be a valuable tool to interrogate telomere maintenance mechanisms and a potential starting point for the development of novel anti-cancer therapeutics targeting the shelterin complex

This is one of the theoretical advantages of the dual GIP/GLP-1 approach over the amylin/GLP-1 approach

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For reaction temperature, the enzymatic reaction was incubated at 4, 10, 20, 30, 40, 50 and 60 C, for 10, 20, 30 and 40 min, and the activity of the enzyme was measured