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To circumvent these pitfalls, robust methods for the determination of metal-protein affinities (usually via competition with well-characterised ligand standards) have been described [[197], [198], [199], [200]]

doi:10.1007/s00253-015-6847-z Harington CR, Mead TR (1935) Synthesis of glutathione

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[7] MOTS-c has been studied in the context of osteoporosis, with findings suggesting it may influence the synthesis of type I collagen in osteoblasts through the TGF-/SMAD signaling pathway