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Currently, treatments based on copper metabolism in cardiovascular disease can encompass a wide range of options, including copper chelating agents [such as triethylenetetramine (TETA), tetrathiomolybdate (TTM) and disodium ethylene diamine tetraacetic acid (EDTA)], small-molecule inhibitors of copper chaperone proteins (such as DCAL50), copper ion carriers and natural antidote agents (Table II)

He reports a history of chronic constipation

Journal of Medicinal Chemistry, 62 (3), 10961115

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doi: 10.4049/jimmunol.173.6.3916

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