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Structurally, semaglutide is a modified peptide analog of human GLP-1, designed to resist enzymatic degradation and prolong its biological half-life, allowing for once-weekly subcutaneous injection

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It is often described as a stable gastric pentadecapeptide, and many studies discuss it through gastric mucosal protection, intestinal tissue models, ulceration-style models, inflammatory bowel-style models and barrier function endpoints

For those with severe deficiencies due to inflammatory bowel disease, this may be necessary for a time, but to truly address the cause of vitamin B12 deficiency, its important to repair the digestive tract

Science 272 , 10231026 (1996)

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