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If these intermediates build up faster than the Krebs cycle can process them, they become highly toxic, effectively choking the mitochondria and halting the entire energy-producing apparatus

ROS-induced oxidative stress can lead to retinal cell damage and dysfunction

stiffness and resistance to limb movement caused by increased muscle tone and/or an excessive and continuous contraction of muscles, which may be uniform (lead-pipe rigidity) or ratchety (cogwheel rigidity), and which may be associated with joint pain

They are necessary as the central acting units of extracellular effector and intracellular signaling systems that regulate anti-inflammatory and antioxidant response and the main transcription programs via NF- B and Nrf2, respectively [27]

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