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Description
Expanded options for pathway profiling are in the graphic below: Functionality biomarkers Cytochrome P450 enzyme activity Albumin production Urea production Clinical liver health biomarkers Lactose dehydrogenase (LDH) release Adenosine Triphosphate (ATP) Aspartate Transferase (AST)/Alanine amino transferase (ALT) Optional profiling analysis Quantitative PCR Transcriptomics Oxidative stress Mitochondrial dysfunction Steatosis Bile acid synthesis/ transport dysregulation Inflammatory response (Human DILI assay only) Proven predictability, reliability and robustness Using a panel of IQ MPS Consortium-recommended reference compounds, the PhysioMimix DILI assay delivered 100% sensitivity, 85% accuracy and 100% precision, outperforming other in vitro approaches

Studies in cultured rat hepatocytes and perfused livers

[DOI] [PubMed] [Google Scholar] 150.Hwang C.L., Bian J.T., Thur L.A., Peters T.A., Piano M.R., Phillips S.A

Mol Biol Rep 51(1):117

Recovery of oligomeric proanthocyanidins and other phenolic compounds with established bioactivity from grape seed by-products
A pilot clinical study showed that daily administration of liposomal glutathione for one month resulted in significant increases in blood and immune cell glutathione levels, without major adverse effects
