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Description
the dimer interface which encompasses the inter-domain linker amino acids (K122, D123, Y124, 1125, R126, and N127) is referred to as the hinge region
The well content was quickly detached using a cell scraper and collected in microcentrifuge tube (Sarstedt), directly snap-frozen in liquid nitrogen, and stored at 80 C until further use
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The pharmacological properties of this herb are primarily ascribed to a diverse range of bioactive constituents, which include phenylpropanoids (such as rosavin, rosarin, and rosin), salidroside, tyrosol, flavonoids, tannins, and essential oils ( 5.2 Mechanisms of action The antidepressant properties of Rhodiola rosea are characterized by a multi-faceted mechanism of action, indicative of its extensive phytochemical composition (Figure 1)

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The let-7 miRNA family deregulates this pathway by governing PI3K and Akt1 phosphorylation and activity [108]
