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Several other additives are commonly offered, each with a different theoretical justification

These may include minor side effects such as a little redness, swelling, or slight bruising at the injection site, which typically resolve quickly

The best-known are GLP-1 receptor agonists such as semaglutide and liraglutide, which have been found to be effective in clinical trials

What actually preserves muscle during weight loss The interventions with the strongest evidence for preserving muscle during rapid weight loss are, in order of evidence strength, resistance training, adequate protein intake (1.0-1.6 grams per kilogram of body weight daily), and possibly creatine supplementation