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Adverse Events/Precautions Rare, but devastating long-term adverse effects of LIS including physical disfigurement and the off-label manner of administration have prevented widespread use of medical-grade LIS

Van Oudenhove L, Demyttenaere K, Tack J, Aziz Q (2004) Central nervous system involvement in functional gastrointestinal disorders

Klicek et al., 2013

The catheter was attached to the right frontal bone of the skull with the Medtronic Stimloc system and then tunneled under the skin into the abdominal region where it was connected to a 20 ml telemetry-adjustable pump delivery system (Prometra II Flowonix), which was buried in a subcutaneous pocket

In these animals, VIP reduced epithelial permeability in the jejunum but had no effect in the ileum, and its effects were not observed when animals were on a high-protein diet

It is crucial to promptly administer thiamine injections, remove high-sulfur carbohydrates from the diet, and facilitate the return of rumen flora to normal