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Immunostaining revealed mixed cell populations with many undifferentiated hPSCs and mesoderm cells, and DE markers SOX17 and FOXA2 were expressed at lower levels compared to the Activin A-based control (CA)

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These results underscore a pivotal role for mPFC-derived CCK in shaping affective responses to social stress and suggest a promising molecular target for intervention in stress-related neuropsychiatric disorders

Note: evidence for true synergistic effects is limited to specific experimental models

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Sedla T, Shufelt C, Iribarren C, et al