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10.1016/s0140-6736(21)00218-x [DOI] [PubMed] [Google Scholar] Cao Y, Tan YJ, Huang D (2024) Molecular mechanism of 5,6-dihydroxyflavone in suppressing LPS-induced inflammation and oxidative stress

126 The upregulation of IDH1 may represent a common metabolic adaptation for diminishing oxidative stress and supporting macromolecular synthesis, consequently promoting tumor growth and therapy resistance

Additionally, as the study populations were restricted to participants from India and Japan, the applicability of these findings to other ethnic groups remains uncertain due to genetic, dietary, and lifestyle differences that influence NAFLD progression and treatment response [100,101,102]

S., Abdelhamid, A

6.4 Emerging perspectives and development trends The intratumoral microbiome field is undergoing a transformative paradigm shift driven by three key innovations: ecological management theories for dynamic microbiome regulation, multi-omics integration enabling precision interventions, and engineering technologies accelerating clinical translation

Results from the present study further corresponded well with this viewpoint in which increment of Fe 2+ expression coincided well with the up-regulation of ATF6, IRE1, PERK, and BAX activities (Figures 5, 6), all are key elements participated in the development of ER stress and apoptosis