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The observed midazolam and dextromethorphan concentration-time profiles were captured within the 5 th and 95 th percentiles of the simulated profiles of the probe drugs administered alone (Figure 4)

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It is not clear whether sex is a predisposing risk factor in humans, but male rodents are considerably more susceptible than females to nephrotoxicity and carcinogenicity from many environmental toxins (NTP, 1983, 1986, 1987)

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