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doi: 10.1016/j.semcdb.2017.07.013 65 PandeyV
The iron-loaded transferrin is then recognized by the cell membrane receptor TfR1 and translocated into endosomes via the receptor-mediated endocytosis pathway, where ferric ions are released from the transferrin in acidic endosomes and then reduced to Fe 2+ by the enzyme prostate 3 metal reductase (STEAP 3) (71)
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