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doi: 10.1073/PNAS.1408148111 20 BarchielliG.CapperucciA.TaniniD

Although most individuals infected with SARS-CoV-2 experience mild-to-moderate disease, a subset fall critically ill and develop acute respiratory distress syndrome (ARDS), which is marked by neutrophil and monocyte extravasation into bronchi, cytokine storms and tissue damage from widespread inflammation

Additionally, SIRT1 plays a role in governing ferroptosis by modulating the expression of GPX4, SLC7A11, and SLC3A2 (You et al., 2021)

Safety signals are poorly tracked

The formation of aggregates is variable and inconsistent and depends on the cell type used and on the experimental conditions of the GST pulldown assay