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Individual responses vary, and hydration is the most consistent and best-supported short-term effect
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Furthermore, they observed a strong negative correlation between TRAP values and high plasma ascorbic acid levels in CF patients, suggesting that high concentrations of ascorbic acid might exert a pro-oxidant effect in the context of CF, thereby diminishing the overall extracellular antioxidant defense (Langley et al., 1993)

Seeing that sort of experience, even for a doctor, stays with you, says Heber
Regular monitoring and patient education about potential side effects are essential components of successful treatment
10.1098/rsta.2013.0309 [DOI] [PMC free article] [PubMed] [Google Scholar] Manzocco, L