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Previous studies indicate that the factors of disc degeneration could be associated with apoptosis, as a reduction in cell numbers leads to decreased ECM protein production and disruptions in cellular energy metabolism and other physiological functions 8

doi: 10.1016/j.jaci.2019.12.910 137 EwingEKularLFernandesSJKarathanasisNLaganiVRuhrmannSet al

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Moderate glutathione synthetase deficiency leads to hemolytic anemia and metabolic acidosis, whereas patients with a more severe deficiency also develop 5-oxoprolinuria, recurrent bacterial infections, and progressive dysfunction of the central nervous system, including mental retardation and motor functional disturbances

That really depends on youyour condition, how long its been going on, and how your body responds to treatment