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Brown and beige adipocytes can be identified morphologically as multilocular and function to convert energy into heat through an uncoupling process that is largely mediated by uncoupling protein 1 (UCP1)

Major source of methyl groups Choline may be oxidized in the liver and kidney to form a metabolite called betaine via a two-step enzymatic reaction

On fitful or recurrent vomiting

The degree of weakness is variable and commonly fatigable

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Clinically, they present as painless black or red lines beneath the distal nail plate, most commonly affecting the fingernails, but also seen under the toenails