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In this Review, Sankar Ghosh and Matthew Hayden discuss the roles of several newly identified regulators of the NF-B pathway, as well as some old factors that have been assigned new functions.
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Overall, these mechanistic insights uncover a passage-associated shift from biosynthetic activity toward redox maintenance and identify the cysteine-glutathione axis as a critical metabolic lever for enhancing long-term stability and productivity in CHO cell culture.
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