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Carboxymethyl lysine (CML), reported as the most abundant AGEs in vivo , is formed by oxidative degradation of Amadori product fructoselysine

Stacking them adds redundant signaling and side-effect risk

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For instance, men with normozoospermia but elevated seminal leukocytes or cytokines may exhibit high DNA fragmentation and poor ART outcomes yet remain categorized as idiopathic under conventional frameworks