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These findings, consistent with the unchanged levels of key proteins detected by Western blot, indicated that PPARa likely does not exert its anti-ferroptotic effects through common mechanisms such as modulating PUFA-PL synthesis, the cyst(e)ine-GSH-GPX4 axis, or iron transport to inhibit the Fenton reaction

Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state

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Insulin: too much of a good thing is bad

[DOI] [PMC free article] [PubMed] [Google Scholar] 543.Baharvand, F

These results help comprehend the potential therapeutic goals of pathways like IR, glucose uptake, oxidative stress, etc