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10.2165/00003495-200363010-00005 172 MacDonald-WicksL

doi: 10.3390/microorganisms11061491 [DOI] [PMC free article] [PubMed] [Google Scholar] 26.Wilson H, Trk ME

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As oxidative stress increases, further stimulation of pro-inflammatory cytokines such as TNF- and IL-1 increases and contributes to synaptic dysfunction and neuronal degeneration ( These studies suggest that the loss of antioxidant defense is an early biochemical event rather than a late-stage consequence of neuronal death

Many patients report benefits, and the mechanisms are well supported

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