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Abnormal neuroinflammatory changes have also been demonstrated, including prominent microglia activation and increased inflammatory cytokine and chemokine production (144146)
7 , eabi8602 (2021)
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Additionally, affected individuals may face rejection or discrimination from peers, romantic partners, and even family members due to their condition [9,14,19]
Indeed, diagnosis after sudden death of infancy was more common before NBS inclusion [118, 119]
