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Of note, 4-hydroxynonenal (4-HNE), as the end-product of lipid peroxidation, could increase the expression of Fas in a concentration- and time-dependent manner, accompanied by the activation of caspase 3 and finally leading to apoptosis [83]

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Notably, chTLR21-mediated transcription of IFN- is dependent on both NF-B and IRF7 signaling pathways, yet it is independent of TBK1 kinase, a distinctive feature that contrasts with mammalian TLR9 signaling ( 4.2 Antioxidant defense Under conditions of oxidative stress, avian erythrocytes demonstrate a substantial antioxidant response

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There are several factors that are involved in generating oxidative stress during diabetes