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It may have to do with normal hormonal changes as you age, but it's not clear

[DOI] [PubMed] [Google Scholar] 201

[DOI] [PubMed] [Google Scholar] 27.Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA: Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone in healthy adults

Say Goodbye to Tired Eyes and Hello to a Fresh, Youthful Look

Mild nausea

Put plainly, the off period is not there because the compound stops working it is there because no one can point to human data showing that running it indefinitely is safe, and a scheduled break is the honest way to respect that gap