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The TIR/BB-loop mimetic AS-1 prevents non-alcoholic steatohepatitis and hepatic insulin resistance by inhibiting NLRP3-ASC inflammasome activation

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Despite the availability of pharmacological, non-pharmacological, and surgical treatments, including brain, spinal, and vagus nerve stimulators, patients continue to experience progressive weakness, and no treatment has yet succeeded as a true disease modifier [13]
Mendez, I

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