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doi: 10.1016/j.cmet.2012.12.011 50 MaJPazosIMGaiF

Animal studies show that long-term carnitine supplementation promotes mitochondrial biogenesis in skeletal muscle, heart, and brain tissue of aging subjects through upregulation of PPAR-coactivator-1 (PGC-1), a master regulator of mitochondrial biosynthesis and function

10.1093/ndt/16.7.1483 Guillaume CP, Stolk L, Dejagere TF, Kooman JP: Successful use of hemodialysis in acute valproic acid intoxication

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Since the body does not store large amounts of water-soluble vitamins, maintaining their potency is important for consistent nutrient intake