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2024 Sep 17;14(9):925
Hains MD, Wing MR, Maddileti S, Siderovski DP, Harden TK
Vitamin C helps to maintain normal immune system function, energy metabolism, and normal collagen, which is needed to maintain normal function of blood vessels, skin, bones and gums
Concretely, the accumulated lactate promotes CIRP lactylation and consequently leads to CIRP release in macrophages, which then binds to ZBP1 in pulmonary vascular endothelial cells (PVECs)
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