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The Fanconi anemia pathway in cancer
This results in the accumulation of triglycerides and, more importantly, toxic lipid and metabolic intermediates that can be primarily attributed to defects in four interrelated pathways: (a) increased uptake of fatty acids from extrahepatic sources including diet and adipose tissue
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Our meta-analysis of 49 murine single-cell datasets revealed that Mtnr1a transcripts were detectable in the lung, whereas Mtnr1b was largely absent ( Supplementary Figure 3A ), whereas in a similar analysis of over 250 human datasets, both Mtnr1a and Mtnr1b were detected ( Supplementary Figure 3B )
