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Mechanistically, SLC25A39 deficiency induced mitochondrial dysfunction, characterized by excessive mitochondrial reactive oxygen species (ROS), reduced membrane potential, diminished adenosine triphosphate (ATP) synthesis, aberrant mitochondrial permeability transition pore (mPTP) opening, and cytochrome c release

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The more common IBD types include ulcerative colitis and Crohn's disease. IBD symptoms include: Blood in stools Pain in the area of the abdomen Fatigue Frequent diarrhea Weight loss (unintentional) IBD can be caused by a poorly-functioning immune system, that specific types of medications can treat. 3