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Description
Radiother Oncol (2013) 109(3):3847
Body composition changes reduced fat, improved muscle response generally become apparent between 36 months
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Thus, these altered metabolomic changes and perturbed balance in the motor cortex of prpTDP-43 A315T mice suggest a deficit in energy homeostasis and increased oxidative stress, events that are associated with problems with mitochondrial integrity and function
Results: Improvements are often seen within 3-7 days, with the full effect taking about 2 weeks
doi: 10.1056/nejmoa1809615
