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While in most patients, it resolves without sequelae, the outcome in refractory vasoplegic states is poor, with an estimated mortality of 25% in patients not responsive to first-line vasopressors [1]

NAD+ is essential for cellular energy and mitochondrial function

Structure of the detoxification catalyst mercuric ion reductase from Bacillus sp
THF may be regenerated via MTR or may be obtained from fresh folate in the diet

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