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The vast majority of information comes from in-vitro and animal studies

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The mechanism may refer to the formation of lipid pore, similar to the proteinaceous pores observed in necroptosis and pyroptosis [25]

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J Pharmacol Exp Ther 289(3):16781687 Moyanova SG, Mastroiacovo F, Kortenska LV, Mitreva RG, Fardone E, Santolini I, Sobrado M, Battaglia G et al (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage