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Upon antigen encounter, successful activation triggers a metabolic shift: Effector T cells upregulate aerobic glycolysis (the Warburg effect) to rapidly generate biosynthetic precursors (nucleotides, amino acids, lipids) necessary for clonal expansion and cytokine production, while still maintaining OXPHOS capacity

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[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Mitter S.K., Song C., Qi X., Mao H., Rao H., Akin D., Lewin A., Grant M., Dunn W., Jr., Ding J., et al