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Extracellular LDH Activity as a Measurement for Cytotoxicity The release of lactate dehydrogenase (LDH) into culture supernatant correlated with the amount of cell death and membrane damage, providing an accurate measure of cellular toxicity

58 Interestingly, the expression of this enzyme does not fulfill an instantaneous snapshot of the blood toxicity, but an average value over a time span of about 2/3 months (corresponding to the mean life of the erythrocyte) as it is exclusively expressed during erythropoiesis

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Here, glutamine it is taken up by diamine acetyltransferase (SAT1) and metabolised back to glutamate and GABA by the action of GLS and glutamic acid decarboxylase, respectively (Reference Verkhratsky, Nedergaard and Hertz53)