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Transcellular and Paracellular Pathways Luminal solutes and ions can pass across the IEB via two main pathways: the transcellular pathway (i.e., through the cells) or the paracellular pathway (i.e., between the cells) (Figure 1)

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Plasma GHK-Cu levels decline with age, from approximately 200 ng/mL at 20 to under 80 ng/mL by 60, paralleling the drop in dermal repair capacity