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CYTOSOLIC AND MITOCHONDRIAL ONE-CARBON METABOLISM GENERATES NADPH One-carbon metabolism integrates the amino acids serine and glycine into the folate and methionine cycles that participate in many diverse biological outputs, including nucleotide synthesis (see Chandel 2020c) and methylation reactions involved in epigenetics (see Chandel 2020d)

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The excessive accumulation of free radicals resulting from this process causes direct oxidative damage to the mitochondrial membrane, inducing necrosis and ultimately leading to cell death

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