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The disc is loaded with compression or shear/distraction, and nucleus pulposus tissue is lost as it herniates either through the ruptured annulus or failed annulus-endplate interface (disc injury type B1) or through the fractures lines of the endplate (disc injury type B3)

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Biomed Pharmacother 110:582593 Butawan M, Benjamin R, Bloomer R, Methylsulfonylmethane (2017) Applications and safety of a Novel Dietary supplement

(2021) Association of mushroom consumption with all-cause and cause-specific mortality among American adults: prospective cohort study findings from NHANES III

That dual role is part of why the research base touches so many systems: skin, hair follicles, wound beds, lung, gut, and bone in animal and cell models