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Similarly, an increase in 4-HNE and several other well defined markers of OS such as nitrotyrosine (NTY), and 8-hydroxy-2-deoxyguanosine (8-OHdG), have also been identified in the interstitial tissue of the ageing mouse ovary 62 , thus creating a strong precedent for the study of 4-HNE in the deterioration of oocyte quality with age

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