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Description
Although the complete molecular mechanism underlying changes in GCL expression during chronic cholestasis or in response to UDCA has not yet been clarified, Yang and colleagues showed a transient and early increase in GSH-related enzymes, followed by their dramatic decrease in a second phase of cholestasis

When levels are low, the immune system may become less effective

This is expected to change, as systems have been established to track the health outcomes of people receiving these medications

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