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Extracellularly, IGSH did accumulate, and no significant ICGS and ICYS formation was observed

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If transient damage to the epithelium occurs, inflammation is triggered and resolved

They are more frequent in the plexuses of the fourth ventricle than in the lateral ventricles, but those in the lateral ventricles are the more important because they may attain large size and, by obstructing the interventricular foramen, cause hydrocephalus leading to dilation and pressure atrophy of the walls of the ventricles (Fig

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The FDA's accelerated approval pathway and the EMA's adaptive pathways program have further intensified Phase II DCT adoption by incentivizing sponsors to generate early efficacy signals from broader, more representative patient populations an objective directly facilitated by hybrid and decentralized enrollment models that extend geographic reach without proportional site network expansion