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K-means clustering analysis of amplicon sequence variants by animal demonstrated that NNMTi-treated DIO mice switched to LD had a distinct microbiome pattern that was highlighted by decreased Erysipelatoclostridium and increased Lactobacillus relative abundances compared to vehicle counterparts

This restoration of metabolic cofactor availability enables enhanced function of NAD+-dependent enzymes including sirtuins, poly(ADP-ribose) polymerases, and various deacetylases that regulate cellular metabolism, stress responses, and aging processes

Scientific Reports 14:15554

B12 is added because it directly supports red blood cell formation, neurological function, and steady daily energy

MIC B12 is designed to complement diet, movement, and your broader plan rather than work as a standalone weight loss treatment

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