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10.1212/WNL.0000000000010404 25 ChaudhuriK

The sustained-release formulation provides prolonged therapeutic activity

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Berberine hydrochloride IL-8 dependently inhibits invasion and IL-8-independently promotes cell apoptosis in MDA-MB-231 cells

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The applicant further stated that in clinical trials, SPEVIGO was associated with clinically significant improvements in patient-reported psoriasis symptoms, including fatigue, and significant decreases in markers of systemic inflammation