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The breast cancer early-onset gene 1 (BRCA1) functions as a guardian of genome stability and has multiple effects on key cellular processes involved in DNA damage repair, transcriptional regulation, ubiquitination and cell cycle control [312]

J Chem Soc Trans 99, 23362341

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Grandjean et al concluded through their meta-analysis of eight trials that oral delivery of NAC at doses ranging from 400 to 1200 mg per day to as little as 600 mg three times per week proved to be superior to placebo in the treatment of chronic bronchitis

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